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Linda Z Penn Selected Research

Fluvastatin

11/2021Quantitative Prostate MRI Analysis Following Fluvastatin Therapy for Localized Prostate Cancer - A Pilot Study.
1/2021The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma.
1/2021Mevalonate Pathway Inhibition Slows Breast Cancer Metastasis via Reduced N-glycosylation Abundance and Branching.
12/2020A pilot window-of-opportunity study of preoperative fluvastatin in localized prostate cancer.
1/2018Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins.
9/2015Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.
1/2014Identifying molecular features that distinguish fluvastatin-sensitive breast tumor cells.
12/2010Differential interactions between statins and P-glycoprotein: implications for exploiting statins as anticancer agents.

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Linda Z Penn Research Topics

Disease

44Neoplasms (Cancer)
04/2022 - 07/2002
9Carcinogenesis
01/2021 - 11/2005
6Prostatic Neoplasms (Prostate Cancer)
04/2022 - 08/2008
6Breast Neoplasms (Breast Cancer)
01/2021 - 05/2009
6Hypercholesterolemia
09/2014 - 09/2004
5Multiple Myeloma
01/2021 - 06/2007
4Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
10/2020 - 09/2004
3Carcinoma (Carcinomatosis)
03/2010 - 07/2002
2Hematologic Neoplasms (Hematological Malignancy)
10/2020 - 09/2014
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
10/2007 - 07/2007
1Inflammation (Inflammations)
04/2022
1Neoplasm Metastasis (Metastasis)
01/2021
1Pancreatic Neoplasms (Pancreatic Cancer)
01/2021
1Leukemia
01/2020
1Genetic Translocation (Chromosomal Translocation)
05/2017
1Brain Ischemia (Cerebral Ischemia)
09/2014
1Septic Shock (Toxic Shock Syndrome)
02/2013
1Infections
02/2013
1Ovarian Neoplasms (Ovarian Cancer)
03/2010
1Ductal Carcinoma
05/2009
1Neuroblastoma
10/2007
1Glioblastoma (Glioblastoma Multiforme)
05/2006
1Medulloblastoma
07/2005
1Squamous Cell Carcinoma of Head and Neck
07/2002

Drug/Important Bio-Agent (IBA)

18Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
04/2022 - 09/2004
15Proteins (Proteins, Gene)FDA Link
01/2021 - 01/2002
14Mevalonic Acid (Mevalonate)IBA
01/2021 - 07/2002
9Oncogene Proteins (Oncogene Protein)IBA
01/2021 - 08/2005
8FluvastatinFDA Link
11/2021 - 12/2010
6Pharmaceutical PreparationsIBA
01/2022 - 03/2010
5Transcription Factors (Transcription Factor)IBA
01/2021 - 05/2003
5Messenger RNA (mRNA)IBA
05/2017 - 07/2007
5Lovastatin (Mevacor)FDA LinkGeneric
12/2010 - 07/2002
4EnzymesIBA
01/2019 - 07/2002
3CholesterolIBA
04/2022 - 01/2019
3Caspase 3 (Caspase-3)IBA
11/2021 - 04/2009
3Biological ProductsIBA
01/2021 - 08/2006
3Small Interfering RNA (siRNA)IBA
01/2021 - 07/2007
3Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)IBA
01/2019 - 07/2002
3Oxidoreductases (Dehydrogenase)IBA
09/2015 - 09/2004
2Biomarkers (Surrogate Marker)IBA
01/2022 - 01/2018
2Polysaccharides (Glycans)IBA
01/2021 - 08/2008
2Dipyridamole (Persantine)FDA LinkGeneric
10/2020 - 09/2014
2SterolsIBA
01/2019 - 09/2015
2geranylgeranyl pyrophosphate (geranylgeranyl diphosphate)IBA
01/2018 - 07/2002
23-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA)IBA
09/2015 - 09/2004
2ChromatinIBA
04/2015 - 11/2010
2Antineoplastic Agents (Antineoplastics)IBA
01/2014 - 06/2010
2Doxorubicin (Adriamycin)FDA LinkGeneric
12/2010 - 03/2010
2Member 1 Subfamily B ATP Binding Cassette TransporterIBA
12/2010 - 03/2010
2Protein Isoforms (Isoforms)IBA
06/2010 - 08/2005
2Coenzyme A (CoA)IBA
06/2010 - 07/2002
1LipidsIBA
04/2022
1Bortezomib (Velcade)FDA Link
01/2021
1CalpainIBA
01/2021
1N-AcetylglucosaminyltransferasesIBA
01/2021
1TubulinIBA
01/2021
1Tubulin ModulatorsIBA
01/2021
1Cilostazol (Pletal)FDA LinkGeneric
10/2020
1Phosphodiesterase InhibitorsIBA
10/2020
1Phosphoric Diester Hydrolases (Phosphodiesterases)IBA
10/2020
1Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA
10/2020
1Adenosine Monophosphate (AMP)IBA
10/2020
1Cyclic AMP (AMP, Cyclic)IBA
10/2020
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
01/2019
1AcetyltransferasesIBA
12/2018
1Histones (Histone)IBA
12/2018
1Histone MethyltransferasesIBA
10/2018
1farnesyl pyrophosphate (farnesyl diphosphate)IBA
01/2018
1Zinc Finger E-box-Binding Homeobox 1IBA
01/2018
1Therapeutic UsesIBA
11/2016
1PalmitatesIBA
03/2015
1Fatty Acids (Saturated Fatty Acids)IBA
03/2015
1Estrogen Receptor alphaIBA
01/2014
1LipopolysaccharidesIBA
02/2013
1CytokinesIBA
02/2013
1Atorvastatin (Lipitor)FDA Link
12/2010
1Rosuvastatin Calcium (Crestor)FDA Link
12/2010
1proteoliposomesIBA
12/2010
1lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA
11/2010
11,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA
11/2010
1DNA (Deoxyribonucleic Acid)IBA
11/2010
1DNA Ligase ATPIBA
11/2010
1diallyl disulfide (diallyl disulphide)IBA
07/2010
1Cisplatin (Platino)FDA LinkGeneric
03/2010
1Generic DrugsIBA
03/2010
1ParaffinIBA
05/2009
1Formaldehyde (Formol)FDA Link
05/2009
1MicroRNAs (MicroRNA)IBA
05/2009
1Adenosine Triphosphate (ATP)IBA
02/2009
1Digoxin (Digitek)FDA LinkGeneric
08/2008
1AgarIBA
10/2007
1CollagenIBA
07/2007
1Complementary DNA (cDNA)IBA
07/2007
1IntegrinsIBA
07/2007
1Untranslated RNA (Noncoding RNA)IBA
05/2006

Therapy/Procedure

7Therapeutics
11/2021 - 11/2005
2Aftercare (After-Treatment)
12/2020 - 01/2020
1Prostatectomy (Retropubic Prostatectomy)
11/2021
1Mammaplasty (Breast Reconstruction)
05/2009